Rebalancing β-Amyloid-Induced Decrease of ATP Level by Amorphous Nano/Micro Polyphosphate: Suppression of the Neurotoxic Effect of Amyloid β-Protein Fragment 25-35

Morbus Alzheimer neuropathology is characterized by an impaired energy homeostasis of brain tissue. We present an approach towards a potential therapy of Alzheimer disease based on the high-energy polymer inorganic polyphosphate (polyP), which physiologically occurs both in the extracellular and in...

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Détails bibliographiques
Publié dans:Int J Mol Sci
Auteurs principaux: Müller, Werner E. G., Wang, Shunfeng, Ackermann, Maximilian, Neufurth, Meik, Steffen, Renate, Mecja, Egherta, Muñoz-Espí, Rafael, Feng, Qingling, Schröder, Heinz C., Wang, Xiaohong
Format: Artigo
Langue:Inglês
Publié: MDPI 2017
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5666835/
https://ncbi.nlm.nih.gov/pubmed/29035351
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms18102154
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