p53 gain‐of‐function mutations increase Cdc7‐dependent replication initiation

Cancer‐associated p53 missense mutants confer gain of function (GOF) and promote tumorigenesis by regulating crucial signaling pathways. However, the role of GOF mutant p53 in regulating DNA replication, a commonly altered pathway in cancer, is less explored. Here, we show that enhanced Cdc7‐depende...

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Detalhes bibliográficos
Publicado no:EMBO Rep
Main Authors: Datta, Arindam, Ghatak, Dishari, Das, Sumit, Banerjee, Taraswi, Paul, Anindita, Butti, Ramesh, Gorain, Mahadeo, Ghuwalewala, Sangeeta, Roychowdhury, Anirban, Alam, Sk Kayum, Das, Pijush, Chatterjee, Raghunath, Dasgupta, Maitrayee, Panda, Chinmay Kumar, Kundu, Gopal C, Roychoudhury, Susanta
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2017
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5666604/
https://ncbi.nlm.nih.gov/pubmed/28887320
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embr.201643347
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