Tanshinone IIA Inhibits β-Catenin Nuclear Translocation and IGF-2R Activation via Estrogen Receptors to Suppress Angiotensin II-Induced H9c2 Cardiomyoblast Cell Apoptosis

Cardiomyopathy involves changes in the myocardial ultra-structure, hypertrophy, apoptosis, fibrosis and inflammation. Angiotensin II (AngII) stimulates the expression of insulin like-growth factors (IGF-2) and IGF-2 receptor (IGF-2R) in H9c2 cardiomyoblasts and subsequently leads to apoptosis. Estro...

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Detalhes bibliográficos
Publicado no:Int J Med Sci
Main Authors: Chen, Ya-Fang, Day, Cecilia Hsuan, Lee, Nien-Hung, Chen, Yu-Feng, Yang, Jaw-Ji, Lin, Chih-Hsueh, Chen, Ray-Jade, Rajendran, Peramaiyan, Viswanadha, Vijaya Padma, Huang, Chih-Yang
Formato: Artigo
Idioma:Inglês
Publicado em: Ivyspring International Publisher 2017
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5666563/
https://ncbi.nlm.nih.gov/pubmed/29104486
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7150/ijms.20396
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