Transient Prepubertal Mifepristone Treatment Normalizes Deficits in Contextual Memory and Neuronal Activity of Adult Male Rats Exposed to Maternal Deprivation

Early life adversity is a well-known risk factor for behavioral dysfunction later in life, including the formation of contextual memory; it is also (transiently) accompanied by hyperactivity of the stress system. We tested whether mifepristone (MIF) treatment, which among other things blocks glucoco...

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Bibliografske podrobnosti
izdano v:eNeuro
Main Authors: Loi, Manila, Sarabdjitsingh, Ratna Angela, Tsouli, Andromachi, Trinh, Stephanie, Arp, Marit, Krugers, Harmen J., Karst, Henk, van den Bos, Ruud, Joëls, Marian
Format: Artigo
Jezik:Inglês
Izdano: Society for Neuroscience 2017
Teme:
New Research
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5666324/
https://ncbi.nlm.nih.gov/pubmed/29098176
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/ENEURO.0253-17.2017
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