Wnt/β-catenin activation and macrophage induction during liver cancer development following steatosis

Obesity confers an independent risk for carcinogenesis. In the liver, steatosis often proceeds cancer formation; however, the mechanisms by which steatosis promotes carcinogenesis is unknown. We hypothesize that steatosis alters the microenvironment to promote proliferation of tumor initiating cells...

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Bibliografiska uppgifter
I publikationen:Oncogene
Huvudupphovsmän: Debebe, A, Medina, V, Chen, C-Y, Mahajan, I M, Jia, C, Fu, D, He, L, Zeng, N, Stiles, B W, Chen, C-L, Wang, M, Aggarwal, K-R, Peng, Z, Huang, J, Chen, J, Li, M, Dong, T, Atkins, S, Borok, Z, Yuan, W, Machida, K, Ju, C, Kahn, M, Johnson, D, Stiles, B L
Materialtyp: Artigo
Språk:Inglês
Publicerad: Nature Publishing Group 2017
Ämnen:
Original Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC5666317/
https://ncbi.nlm.nih.gov/pubmed/28671671
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2017.207
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