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Human microbiome signatures of differential colorectal cancer drug metabolism
It is well appreciated that microbial metabolism of drugs can influence treatment efficacy. Microbial β-glucuronidases in the gut can reactivate the excreted, inactive metabolite of irinotecan, a first-line chemotherapeutic for metastatic colorectal cancer. Reactivation causes adverse drug responses...
Uloženo v:
| Vydáno v: | NPJ Biofilms Microbiomes |
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| Hlavní autoři: | , , , |
| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
Nature Publishing Group UK
2017
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5665930/ https://ncbi.nlm.nih.gov/pubmed/29104759 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41522-017-0034-1 |
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