Effect of Selumetinib and MK-2206 vs Oxaliplatin and Fluorouracil in Patients With Metastatic Pancreatic Cancer After Prior Therapy: SWOG S1115 Study Randomized Clinical Trial

IMPORTANCE: KRAS mutations are very common in pancreatic cancer, but directly targeting the KRAS protein has thus far been unsuccessful. The aim of this trial was to block the MEK and PI3K/AKT pathways downstream of the KRAS protein as an alternate treatment strategy to slow cancer growth and prolon...

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Udgivet i:JAMA Oncol
Main Authors: Chung, Vincent, McDonough, Shannon, Philip, Philip A., Cardin, Dana, Wang-Gillam, Andrea, Hui, Laifong, Tejani, Mohamedtaki A., Seery, Tara E., Dy, Irene A., Baghdadi, Tareq Al, Hendifar, Andrew E., Doyle, L. Austin, Lowy, Andrew M., Guthrie, Katherine A., Blanke, Charles D., Hochster, Howard S.
Format: Artigo
Sprog:Inglês
Udgivet: 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5665683/
https://ncbi.nlm.nih.gov/pubmed/27978579
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1001/jamaoncol.2016.5383
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