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Loss of perilipin 2 in cultured myotubes enhances lipolysis and redirects the metabolic energy balance from glucose oxidation towards fatty acid oxidation

Lipid droplet (LD) coating proteins are essential for the formation and stability of intracellular LDs. Plin2 is an abundant LD coating protein in skeletal muscle, but its importance for muscle function is unclear. We show that myotubes established from Plin2(−/−) mice contain reduced content of LDs...

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Pubblicato in:J Lipid Res
Autori principali: Feng, Yuan Z., Lund, Jenny, Li, Yuchuan, Knabenes, Irlin K., Bakke, Siril S., Kase, Eili T., Lee, Yun K., Kimmel, Alan R., Thoresen, G. Hege, Rustan, Arild Christian, Dalen, Knut Tomas
Natura: Artigo
Lingua:Inglês
Pubblicazione: The American Society for Biochemistry and Molecular Biology 2017
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5665670/
https://ncbi.nlm.nih.gov/pubmed/28822960
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.M079764
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