Conserved cytoplasmic domains promote Hrd1 ubiquitin ligase complex formation for ER-associated degradation (ERAD)

The mammalian ubiquitin ligase Hrd1 is the central component of a complex facilitating degradation of misfolded proteins during the ubiquitin–proteasome-dependent process of ER-associated degradation (ERAD). Hrd1 associates with cofactors to execute ERAD, but their roles and how they assemble with H...

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Publicado en:J Cell Sci
Autores principales: Schulz, Jasmin, Avci, Dönem, Queisser, Markus A., Gutschmidt, Aljona, Dreher, Lena-Sophie, Fenech, Emma J., Volkmar, Norbert, Hayashi, Yuki, Hoppe, Thorsten, Christianson, John C.
Formato: Artigo
Lenguaje:Inglês
Publicado: The Company of Biologists Ltd 2017
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Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5665440/
https://ncbi.nlm.nih.gov/pubmed/28827405
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.206847
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