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Prebiotic stereoselective synthesis of purine and noncanonical pyrimidine nucleotide from nucleobases and phosphorylated carbohydrates

According to a current “RNA first” model for the origin of life, RNA emerged in some form on early Earth to become the first biopolymer to support Darwinism here. Threose nucleic acid (TNA) and other polyelectrolytes are also considered as the possible first Darwinian biopolymer(s). This model is be...

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Veröffentlicht in:Proc Natl Acad Sci U S A
Hauptverfasser: Kim, Hyo-Joong, Benner, Steven A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2017
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5664531/
https://ncbi.nlm.nih.gov/pubmed/29073050
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1710778114
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