M344 promotes nonamyloidogenic amyloid precursor protein processing while normalizing Alzheimer’s disease genes and improving memory

Alzheimer’s disease (AD) comprises multifactorial ailments for which current therapeutic strategies remain insufficient to broadly address the underlying pathophysiology. Epigenetic gene regulation relies upon multifactorial processes that regulate multiple gene and protein pathways, including those...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Volmar, Claude-Henry, Salah-Uddin, Hasib, Janczura, Karolina J., Halley, Paul, Lambert, Guerline, Wodrich, Andrew, Manoah, Sivan, Patel, Nidhi H., Sartor, Gregory C., Mehta, Neil, Miles, Nancy T. H., Desse, Sachi, Dorcius, David, Cameron, Michael D., Brothers, Shaun P., Wahlestedt, Claes
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2017
Assuntos:
PNAS Plus
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5664514/
https://ncbi.nlm.nih.gov/pubmed/29073110
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1707544114
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