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Intestinal alkaline phosphatase administration in newborns decreases systemic inflammatory cytokine expression in a neonatal necrotizing enterocolitis rat model

BACKGROUND: Supplementation of intestinal alkaline phosphatase (IAP), an endogenous protein expressed in the intestines, decreases the severity of necrotizing enterocolitis (NEC)–associated intestinal injury and permeability. We hypothesized that IAP administration is protective in a dose-dependent...

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Detalhes bibliográficos
Publicado no:J Surg Res
Main Authors: Rentea, Rebecca M., Liedel, Jennifer L., Fredrich, Katherine, Welak, Scott R., Pritchard, Kirkwood A., Oldham, Keith T., Simpson, Pippa M., Gourlay, David M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5664150/
https://ncbi.nlm.nih.gov/pubmed/22687880
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jss.2012.05.039
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