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Third time lucky? Getting a grip on matrix metalloproteinases
Drug candidates against matrix metalloproteinases (MMPs) failed in the clinic in the past because their strong zinc-targeting warheads led to a lack of specificity. More recently, significant selectivity among MMPs was achieved by blocking the enzymes' specificity pockets, nearby exosites, and...
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| Pubblicato in: | J Biol Chem |
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| Autore principale: | |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
American Society for Biochemistry and Molecular Biology
2017
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5663894/ https://ncbi.nlm.nih.gov/pubmed/29079642 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.H117.806075 |
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