Sensorimotor control of breathing in the mdx mouse model of Duchenne muscular dystrophy

KEY POINTS: Respiratory failure is a leading cause of mortality in Duchenne muscular dystrophy (DMD), but little is known about the control of breathing in DMD and animal models. We show that young (8 weeks of age) mdx mice hypoventilate during basal breathing due to reduced tidal volume. Basal CO(2...

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Publicat a:J Physiol
Autors principals: Burns, David P., Roy, Arijit, Lucking, Eric F., McDonald, Fiona B., Gray, Sam, Wilson, Richard J., Edge, Deirdre, O'Halloran, Ken D.
Format: Artigo
Idioma:Inglês
Publicat: John Wiley and Sons Inc. 2017
Matèries:
Respiratory
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5663834/
https://ncbi.nlm.nih.gov/pubmed/28952155
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/JP274792
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