MyD88-dependent inflammasome activation and autophagy inhibition contributes to Ehrlichia-induced liver injury and toxic shock

Severe hepatic inflammation is a common cause of acute liver injury following systemic infection with Ehrlichia, obligate Gram-negative intracellular bacteria that lack lipopolysaccharide (LPS). We have previously shown that type I IFN (IFN-I) and inflammasome activation are key host-pathogenic medi...

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Detalhes bibliográficos
Publicado no:PLoS Pathog
Main Authors: Kader, Muhamuda, Alaoui-EL-Azher, Mounia, Vorhauer, Jennie, Kode, Bhushan B, Wells, Jakob Z., Stolz, Donna, Michalopoulos, George, Wells, Alan, Scott, Melanie, Ismail, Nahed
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2017
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5663626/
https://ncbi.nlm.nih.gov/pubmed/29049365
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1006644
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