Trastuzumab distribution in an in-vivo and in-vitro model of brain metastases of breast cancer

BACKGROUND: Drug and antibody delivery to brain metastases has been highly debated in the literature. The blood-tumor barrier (BTB) is more permeable than the blood-brain barrier (BBB), and has shown to have highly functioning efflux transporters and barrier properties, which limits delivery of targ...

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Опубликовано в: :Oncotarget
Главные авторы: Terrell-Hall, Tori B., Nounou, Mohamed Ismail, El-Amrawy, Fatema, Griffith, Jessica I.G., Lockman, Paul R.
Формат: Artigo
Язык:Inglês
Опубликовано: Impact Journals LLC 2017
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Research Paper
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5663550/
https://ncbi.nlm.nih.gov/pubmed/29137378
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.19634
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