HLA-DRB1 and DQB1 alleles in Japanese type 1 autoimmune hepatitis: The predisposing role of the DR4/DR8 heterozygous genotype

OBJECTIVE: Autoimmune hepatitis (AIH) is a chronic progressive liver disease. AIH is composed predominantly of type 1 in Japanese populations. The genetic and environmental factors are associated with the pathogenesis of AIH. HLA-DRB1*03:01 and *04:01 are associated with type 1 AIH in European and *...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Oka, Shomi, Furukawa, Hiroshi, Yasunami, Michio, Kawasaki, Aya, Nakamura, Hitomi, Nakamura, Minoru, Komori, Atsumasa, Abiru, Seigo, Nagaoka, Shinya, Hashimoto, Satoru, Naganuma, Atsushi, Naeshiro, Noriaki, Yoshizawa, Kaname, Yamashita, Haruhiro, Ario, Keisuke, Ohta, Hajime, Sakai, Hironori, Yabuuchi, Iwao, Takahashi, Atsushi, Abe, Kazumichi, Yatsuhashi, Hiroshi, Tohma, Shigeto, Ohira, Hiromasa, Tsuchiya, Naoyuki, Migita, Kiyoshi
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2017
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5663488/
https://ncbi.nlm.nih.gov/pubmed/29088299
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0187325
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