Non-small cell lung cancer (NSCLC), EGFR downstream pathway activation and TKI targeted therapies sensitivity: Effect of the plasma membrane-associated NEU3

Adenocarcinoma of Non-Small Cell Lung Cancer (NSCLC) is a severe disease. Patients carrying EGFR mutations may benefit from EGFR targeted therapies (e.g.: gefitinib). Recently, it has been shown that sialidase NEU3 directly interacts and regulates EGFR. In this work, we investigate the effect of sia...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Forcella, Matilde, Oldani, Monica, Epistolio, Samantha, Freguia, Stefania, Monti, Eugenio, Fusi, Paola, Frattini, Milo
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2017
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5663482/
https://ncbi.nlm.nih.gov/pubmed/29088281
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0187289
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