Transferrin-conjugated liposomes loaded with novel dihydroquinoline derivatives as potential anticancer agents

A series of 1,2-dihydroquinoline derivatives were synthesized and evaluated for cytotoxicity in HeLa, Hep G2 and 6HEK-293T cell lines. EEDQ2 was identified as a promising anti-cancer agent with low IC(50) in HeLa (18.55μg/ml) and Hep G2 (14.53μg/ml) cells. For improving the antitumor activity and tu...

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Опубликовано в: :PLoS One
Главные авторы: Wang, Mengqiao, Lee, Robert J., Bi, Ye, Li, Lianlian, Yan, Guodong, Lu, Jiahui, Meng, Qingfan, Teng, Lesheng, Xie, Jing
Формат: Artigo
Язык:Inglês
Опубликовано: Public Library of Science 2017
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Research Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5663382/
https://ncbi.nlm.nih.gov/pubmed/29088257
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0186821
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