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Immunogenicity of glycans on biotherapeutic drugs produced in plant expression systems—The taliglucerase alfa story
Plants are a promising alternative for the production of biotherapeutics. Manufacturing in-planta adds plant specific glycans. To understand immunogenic potential of these glycans, we developed a validated method to detect plant specific glycan antibodies in human serum. Using this assay, low preval...
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| Publicado no: | PLoS One |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Public Library of Science
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5663370/ https://ncbi.nlm.nih.gov/pubmed/29088235 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0186211 |
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