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Rationale for adjunctive therapies targeting inflammation pathobiology based phenotypes in pediatric sepsis; from Meningococcemia/atypical Hemolytic Uremic Syndrome, to H1N1 Influenza/Methicillin Resistant Staphylococcus Aureus, to Critical Pertussis, to Epstein Barr Virus Lymphoproliferative Disease, to Ebola and other Viral Hemorrhagic Fevers

Adjunctive therapies have been proposed for use in at least 5 inflammation pathobiology phenotypes in pediatric sepsis-induced multiple organ failure (MOF). Here, we provide host-pathogen interaction prototypes to facilitate understanding of the rationale for personalized therapy in these phenotypes...

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Veröffentlicht in:Pediatr Clin North Am
Hauptverfasser: Podd, Bradley S., Simon, Dennis W., Lopez, Santiago, Nowalk, Andrew, Aneja, Rajesh, Carcillo, Joseph A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2017
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5663307/
https://ncbi.nlm.nih.gov/pubmed/28941536
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.pcl.2017.06.007
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