Low-dose tolvaptan PK/PD: comparison of patients with hyponatremia due to syndrome of inappropriate antidiuretic hormone secretion to healthy adults

PURPOSE: Tolvaptan (TLV) is indicated to treat hyponatremia due to syndrome of inappropriate diuretic hormone (SIADH) in Europe. Treatment is to be initiated at 15 mg QD but post-approval reporting indicates increasing use of 7.5 mg as the starting dose. Physicians believe 7.5 mg is effective and ha...

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Bibliografiske detaljer
Udgivet i:Eur J Clin Pharmacol
Main Authors: Shoaf, Susan E., Bricmont, Patricia, Dandurand, Ann
Format: Artigo
Sprog:Inglês
Udgivet: Springer Berlin Heidelberg 2017
Fag:
Pharmacodynamics
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5662662/
https://ncbi.nlm.nih.gov/pubmed/28803333
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00228-017-2302-7
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