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Phosphorylation and nuclear transit modulate the balance between normal function and terminal aggregation of the yeast RNA-binding protein Ssd1

Yeast Ssd1 is an RNA-binding protein that shuttles between the nucleus and cytoplasm. Ssd1 interacts with its target mRNAs initially during transcription by binding through its N-terminal prion-like domain (PLD) to the C-terminal domain of RNA polymerase II. Ssd1 subsequently targets mRNAs acquired...

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Pubblicato in:Mol Biol Cell
Autori principali: Kurischko, Cornelia, Broach, James R.
Natura: Artigo
Lingua:Inglês
Pubblicazione: The American Society for Cell Biology 2017
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5662262/
https://ncbi.nlm.nih.gov/pubmed/28877986
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E17-02-0100
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