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Tracing the origin of the NS1 A188V substitution responsible for recent enhancement of Zika virus Asian genotype infectivity

A recent study showed that infectivity of Zika virus (ZIKV) Asian genotype was enhanced by an alanine-to-valine amino acid substitution at residue 188 of the NS1 protein, but the precise time and location of origin of this mutation were not formally estimated. Here, we applied a Bayesian coalescent-...

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Bibliographic Details
Published in:Mem Inst Oswaldo Cruz
Main Authors: Delatorre, Edson, Mir, Daiana, Bello, Gonzalo
Format: Artigo
Language:Inglês
Published: Instituto Oswaldo Cruz, Ministério da Saúde 2017
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5661894/
https://ncbi.nlm.nih.gov/pubmed/28876359
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1590/0074-02760170299
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