Ageing affects chondroitin sulfates and their synthetic enzymes in the intervertebral disc

The depletion of chondroitin sulfates (CSs) within the intervertebral disc (IVD) during degenerative disc disease (DDD) results in a decrease in tissue hydration, a loss of fluid movement, cell apoptosis, a loss of nerve growth inhibition and ultimately, the loss of disc function. To date, little is...

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Detalhes bibliográficos
Publicado no:Signal Transduct Target Ther
Main Authors: Collin, Estelle C, Carroll, Oliver, Kilcoyne, Michelle, Peroglio, Marianna, See, Eugene, Hendig, Doris, Alini, Mauro, Grad, Sibylle, Pandit, Abhay
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5661628/
https://ncbi.nlm.nih.gov/pubmed/29263929
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sigtrans.2017.49
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