Fibromodulin reduces scar formation in adult cutaneous wounds by eliciting a fetal-like phenotype

Blocking transforming growth factor (TGF)β1 signal transduction has been a central strategy for scar reduction; however, this approach appears to be minimally effective. Here, we show that fibromodulin (FMOD), a 59-kD small leucine-rich proteoglycan critical for normal collagen fibrillogenesis, sign...

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Publicat a:Signal Transduct Target Ther
Autors principals: Zheng, Zhong, James, Aaron W, Li, Chenshuang, Jiang, Wenlu, Wang, Joyce Z, Chang, Grace X, Lee, Kevin S, Chen, Feng, Berthiaume, Emily A, Chen, Yao, Pan, Hsin Chuan, Chen, Eric C, Li, Weiming, Zhao, Zhihe, Zhang, Xinli, Ting, Kang, Soo, Chia
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2017
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5661627/
https://ncbi.nlm.nih.gov/pubmed/29201497
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sigtrans.2017.50
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