Yap/Taz Deletion in Gli(+) Cell-Derived Myofibroblasts Attenuates Fibrosis

In damaged kidneys, increased extracellular matrix (ECM) and tissue stiffness stimulate kidney fibrosis through incompletely characterized molecular mechanisms. The transcriptional coactivators yes-associated protein (Yap) and transcriptional coactivator with PDZ-binding motif (Taz) function as mech...

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Bibliografiske detaljer
Udgivet i:J Am Soc Nephrol
Main Authors: Liang, Ming, Yu, Michael, Xia, Ruohan, Song, Ke, Wang, Jun, Luo, Jinlong, Chen, Guang, Cheng, Jizhong
Format: Artigo
Sprog:Inglês
Udgivet: American Society of Nephrology 2017
Fag:
Basic Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5661271/
https://ncbi.nlm.nih.gov/pubmed/28768710
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2015121354
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