Endothelial microparticles released by activated protein C protect beta cells through EPCR/PAR1 and annexin A1/FPR2 pathways in islets

Islet transplantation is associated with early ischaemia/reperfusion, localized coagulation and redox‐sensitive endothelial dysfunction. In animal models, islet cytoprotection by activated protein C (aPC) restores islet vascularization and protects graft function, suggesting that aPC triggers variou...

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Pubblicato in:J Cell Mol Med
Autori principali: Kreutter, Guillaume, Kassem, Mohamad, El Habhab, Ali, Baltzinger, Philippe, Abbas, Malak, Boisrame‐Helms, Julie, Amoura, Lamia, Peluso, Jean, Yver, Blandine, Fatiha, Zobairi, Ubeaud‐Sequier, Geneviève, Kessler, Laurence, Toti, Florence
Natura: Artigo
Lingua:Inglês
Pubblicazione: John Wiley and Sons Inc. 2017
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Original Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5661261/
https://ncbi.nlm.nih.gov/pubmed/28524456
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/jcmm.13191
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