Controversial Effects of D-Amino Acid Oxidase Activator (DAOA)/G72 on D-Amino Acid Oxidase (DAO) Activity in Human Neuronal, Astrocyte and Kidney Cell Lines: The N-methyl D-aspartate (NMDA) Receptor Hypofunction Point of View

Dysfunction of D-amino acid oxidase (DAO) and DAO activator (DAOA)/G72 genes have been linked to neuropsychiatric disorders. The glutamate hypothesis of schizophrenia has proposed that increased DAO activity leads to decreased D-serine, which subsequently may lead to N-methyl-D-aspartate (NMDA) rece...

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Detalhes bibliográficos
Publicado no:Front Mol Neurosci
Main Authors: Jagannath, Vinita, Brotzakis, Zacharias Faidon, Parrinello, Michele, Walitza, Susanne, Grünblatt, Edna
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2017
Assuntos:
Neuroscience
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5660716/
https://ncbi.nlm.nih.gov/pubmed/29114206
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnmol.2017.00342
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