Microvascular ultrastructural changes precede cognitive impairment in the murine APPswe/PS1dE9 model of Alzheimer’s disease

Cerebral and systemic organ microvascular pathologies coexist with human Alzheimer’s disease (AD) neuropathology. In this study, we hypothesised that both cerebral and systemic microvascular pathologies exist in 4- to 5-month-old male APPswe/PS1dE9 (APP/PS1) transgenic mice prior to the onset of cog...

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Publicat a:Angiogenesis
Autors principals: Kelly, Patricia, Denver, Paul, Satchell, Simon C., Ackermann, Maximilian, Konerding, Moritz A., Mitchell, Christopher A.
Format: Artigo
Idioma:Inglês
Publicat: Springer Netherlands 2017
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Original Paper
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5660145/
https://ncbi.nlm.nih.gov/pubmed/28741167
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10456-017-9568-3
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