A neuroprotective astrocyte state is induced by neuronal signal EphB1 but fails in ALS models

Astrocyte responses to neuronal injury may be beneficial or detrimental to neuronal recovery, but the mechanisms that determine these different responses are poorly understood. Here we show that ephrin type-B receptor 1 (EphB1) is upregulated in injured motor neurons, which in turn can activate astr...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Tyzack, Giulia E., Hall, Claire E., Sibley, Christopher R., Cymes, Tomasz, Forostyak, Serhiy, Carlino, Giulia, Meyer, Ione F., Schiavo, Giampietro, Zhang, Su-Chun, Gibbons, George M., Newcombe, Jia, Patani, Rickie, Lakatos, András
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5660125/
https://ncbi.nlm.nih.gov/pubmed/29079839
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-01283-z
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