CaMKII-mediated Beclin 1 phosphorylation regulates autophagy that promotes degradation of Id and neuroblastoma cell differentiation

Autophagy is a degradative pathway that delivers cellular components to the lysosome for degradation. The role of autophagy in cell differentiation is poorly understood. Here we show that CaMKII can directly phosphorylate Beclin 1 at Ser90 to promote K63-linked ubiquitination of Beclin 1 and activat...

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Veröffentlicht in:Nat Commun
Hauptverfasser: Li, Xuan, Wu, Xiao-Qi, Deng, Rong, Li, Dan-Dan, Tang, Jun, Chen, Wen-Dan, Chen, Jing-Hong, Ji, Jiao, Jiao, Lin, Jiang, Shan, Yang, Fen, Feng, Gong-Kan, Senthilkumar, Ravichandran, Yue, Fei, Zhang, Hai-Liang, Wu, Rui-Yan, Yu, Yan, Xu, Xue-Lian, Mai, Jia, Li, Zhi-Ling, Peng, Xiao-Dan, Huang, Yun, Huang, Xiang, Ma, Ning-Fang, Tao, Qian, Zeng, Yi-Xin, Zhu, Xiao-Feng
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2017
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5660092/
https://ncbi.nlm.nih.gov/pubmed/29079782
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-01272-2
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