Kisspeptin and Neurokinin B Signaling Network Underlies the Pubertal Increase in GnRH Release in Female Rhesus Monkeys

Loss-of-function or inactivating mutations in the genes coding for kisspeptin and its receptor (KISS1R) or neurokinin B (NKB) and the NKB receptor (NK3R) in humans result in a delay in or the absence of puberty. However, precise mechanisms of kisspeptin and NKB signaling in the regulation of the pub...

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Detalhes bibliográficos
Publicado no:Endocrinology
Principais autores: Garcia, James P., Guerriero, Kathryn A., Keen, Kim L., Kenealy, Brian P., Seminara, Stephanie B., Terasawa, Ei
Formato: Artigo
Idioma:Inglês
Publicado em: Endocrine Society 2017
Assuntos:
Special Section: Targeting and Regulation of Hormone Signaling
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5659687/
https://ncbi.nlm.nih.gov/pubmed/28977601
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/en.2017-00500
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