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Hyperandrogenemia Induced by Letrozole Treatment of Pubertal Female Mice Results in Hyperinsulinemia Prior to Weight Gain and Insulin Resistance

Women with polycystic ovary syndrome (PCOS) diagnosed with hyperandrogenism and ovulatory dysfunction have an increased risk of developing metabolic disorders, including type 2 diabetes and cardiovascular disease. We previously developed a model that uses letrozole to elevate endogenous testosterone...

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Bibliografske podrobnosti
izdano v:Endocrinology
Main Authors: Skarra, Danalea V., Hernández-Carretero, Angelina, Rivera, Alissa J., Anvar, Arya R., Thackray, Varykina G.
Format: Artigo
Jezik:Inglês
Izdano: Endocrine Society 2017
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5659661/
https://ncbi.nlm.nih.gov/pubmed/28911175
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/en.2016-1898
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