Peptide mimetics of immunoglobulin A (IgA) and FcαRI block IgA‐induced human neutrophil activation and migration

The cross‐linking of the IgA Fc receptor (FcαRI) by IgA induces release of the chemoattractant LTB4, thereby recruiting neutrophils in a positive feedback loop. IgA autoantibodies of patients with autoimmune blistering skin diseases therefore induce massive recruitment of neutrophils, resulting in s...

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Dettagli Bibliografici
Pubblicato in:Eur J Immunol
Autori principali: Heineke, Marieke H., van der Steen, Lydia P.E., Korthouwer, Rianne M., Hage, J. Joris, Langedijk, Johannes P.M., Benschop, Joris J., Bakema, Jantine E., Slootstra, Jerry W., van Egmond, Marjolein
Natura: Artigo
Lingua:Inglês
Pubblicazione: John Wiley and Sons Inc. 2017
Soggetti:
Immunomodulation and immune therapies
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5659136/
https://ncbi.nlm.nih.gov/pubmed/28736835
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/eji.201646782
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