Intestinal cancer progression by mutant p53 through the acquisition of invasiveness associated with complex glandular formation

Tumor suppressor TP53 is frequently mutated in colorectal cancer (CRC), and most mutations are missense type. Although gain-of-functions by mutant p53 have been demonstrated experimentally, the precise mechanism for malignant progression in in vivo tumors remains unsolved. We generated Apc(Δ716) Trp...

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Detalhes bibliográficos
Publicado no:Oncogene
Main Authors: Nakayama, M, Sakai, E, Echizen, K, Yamada, Y, Oshima, H, Han, T-S, Ohki, R, Fujii, S, Ochiai, A, Robine, S, Voon, D C, Tanaka, T, Taketo, M M, Oshima, M
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2017
Assuntos:
Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5658682/
https://ncbi.nlm.nih.gov/pubmed/28628120
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2017.194
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