The homeodomain-interacting protein kinase HPK-1 preserves protein homeostasis and longevity through master regulatory control of the HSF-1 chaperone network and TORC1-restricted autophagy in Caenorhabditis elegans

An extensive proteostatic network comprised of molecular chaperones and protein clearance mechanisms functions collectively to preserve the integrity and resiliency of the proteome. The efficacy of this network deteriorates during aging, coinciding with many clinical manifestations, including protei...

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Detalhes bibliográficos
Publicado no:PLoS Genet
Main Authors: Das, Ritika, Melo, Justine A., Thondamal, Manjunatha, Morton, Elizabeth A., Cornwell, Adam B., Crick, Beresford, Kim, Joung Heon, Swartz, Elliot W., Lamitina, Todd, Douglas, Peter M., Samuelson, Andrew V.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2017
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5658188/
https://ncbi.nlm.nih.gov/pubmed/29036198
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1007038
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