Pre-S2 Mutant-Induced Mammalian Target of Rapamycin Signal Pathways as Potential Therapeutic Targets for Hepatitis B Virus-Associated Hepatocellular Carcinoma

Chronic hepatitis B virus (HBV) infection is a major risk factor for hepatocellular carcinoma (HCC). Pre-S2 mutant represents an HBV oncoprotein that is accumulated in the endoplasmic reticulum (ER) and manifests as type II ground glass hepatocytes (GGHs). Pre-S2 mutant can induce ER stress and init...

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Bibliographic Details
Published in:Cell Transplant
Main Authors: Teng, Chiao-Fang, Wu, Han-Chieh, Shyu, Woei-Cherng, Jeng, Long-Bin, Su, Ih-Jen
Format: Artigo
Language:Inglês
Published: SAGE Publications 2017
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Review
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5657708/
https://ncbi.nlm.nih.gov/pubmed/28195035
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3727/096368916X694382
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