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Physiologic Doses of Bilirubin Contribute to Tolerance of Islet Transplants by Suppressing the Innate Immune Response

Bilirubin has been recognized as a powerful cytoprotectant when used at physiologic doses and was recently shown to have immunomodulatory effects in islet allograft transplantation, conveying donor-specific tolerance in a murine model. We hypothesized that bilirubin, an antioxidant, acts to suppress...

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Detalhes bibliográficos
Publicado no:Cell Transplant
Main Authors: Adin, Christopher A., Vangundy, Zachary C., Papenfuss, Tracey L., Xu, Feng, Ghanem, Mostafa, Lakey, Jonathan, Hadley, Gregg A.
Formato: Artigo
Idioma:Inglês
Publicado em: SAGE Publications 2017
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5657680/
https://ncbi.nlm.nih.gov/pubmed/27393133
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3727/096368916X692096
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