The impact of ageing reveals distinct roles for human dentate gyrus and CA3 in pattern separation and object recognition memory

Both recognition of familiar objects and pattern separation, a process that orthogonalises overlapping events, are critical for effective memory. Evidence is emerging that human pattern separation requires dentate gyrus. Dentate gyrus is intimately connected to CA3 where, in animals, an autoassociat...

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Udgivet i:Sci Rep
Main Authors: Dillon, Serena E., Tsivos, Demitra, Knight, Michael, McCann, Bryony, Pennington, Catherine, Shiel, Anna I., Conway, Myra E., Newson, Margaret A., Kauppinen, Risto A., Coulthard, Elizabeth J.
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5656671/
https://ncbi.nlm.nih.gov/pubmed/29070813
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-13853-8
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