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A formulation of pancreatic pro-enzymes provides potent anti-tumour efficacy: a pilot study focused on pancreatic and ovarian cancer

Proteolytic enzymes have shown efficacy in cancer therapy. We present a combination of the two pro-enzymes Trypsinogen and Chymotrypsinogen A with potent in vitro and in vivo anti-tumour efficacy. A synergetic anti-tumour effect for Trypsinogen and Chymotrypsinogen A was determined at a ratio 1:6 (n...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Perán, Macarena, López-Ruiz, Elena, García, María Ángel, Nadaraia-Hoke, Shorena, Brandt, Ralf, Marchal, Juan A., Kenyon, Julian
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5656641/
https://ncbi.nlm.nih.gov/pubmed/29070896
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-14571-x
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