Combined immunotherapy with anti-PDL-1/PD-1 and anti-CD4 antibodies cures syngeneic disseminated neuroblastoma

Anti-PD-1 or anti-PD-L1 blocking monoclonal antibodies (mAbs) have shown potent anti-tumor effects in adult cancer patients and clinical studies have recently been started in pediatric cancers, including high-risk/relapsing neuroblastoma (NB). Therefore, we studied the effects of anti-PD-1/PD-L1 mAb...

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Bibliografske podrobnosti
izdano v:Sci Rep
Main Authors: Rigo, Valentina, Emionite, Laura, Daga, Antonio, Astigiano, Simonetta, Corrias, Maria Valeria, Quintarelli, Concetta, Locatelli, Franco, Ferrini, Silvano, Croce, Michela
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group UK 2017
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5656588/
https://ncbi.nlm.nih.gov/pubmed/29070883
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-14417-6
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