Penetrance estimate of LRRK2 p.G2019S Mutation in Individuals of Non-Ashkenazi Jewish Ancestry

BACKGROUND: Penetrance estimates of the LRRK2 p.G2019S mutation for Parkinson’s disease (PD) vary widely (24%–100%). The p.G2019S penetrance in individuals of Ashkenazi Jewish ancestry has been estimated as 25%, adjusted for multiple covariates. It is unknown whether penetrance varies among differen...

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Publicado no:Mov Disord
Main Authors: Lee, Annie J., Wang, Yuanjia, Alcalay, Roy N., Mejia-Santana, Helen, Saunders-Pullman, Rachel, Bressman, Susan, Corvol, Jean-Christophe, Brice, Alexis, Lesage, Suzanne, Mangone, Graziella, Tolosa, Eduardo, Pont-Sunyer, Claustre, Vilas, Dolores, Schüle, Birgitt, Kausar, Farah, Foroud, Tatiana, Berg, Daniela, Brockmann, Kathrin, Goldwurm, Stefano, Siri, Chiara, Asselta, Rosanna, Ruiz-Martinez, Javier, Mondragón, Elisabet, Marras, Connie, Ghate, Taneera, Giladi, Nir, Mirelman, Anat, Marder, Karen, Fox, Michael J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5656509/
https://ncbi.nlm.nih.gov/pubmed/28639421
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/mds.27059
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