Optimal timing for the oral administration of Da-Cheng-Qi decoction based on the pharmacokinetic and pharmacodynamic targeting of the pancreas in rats with acute pancreatitis

AIM: To identify the optimal oral dosing time of Da-Cheng-Qi decoction (DCQD) in rats with acute pancreatitis (AP) based on the pharmacokinetic and pharmacodynamic parameters. METHODS: First, 24 male Sprague-Dawley rats were divided into a sham-operated group [NG(a)] and three model groups [4hG(a),...

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Vydáno v:World J Gastroenterol
Hlavní autoři: Zhang, Yu-Mei, Zhu, Lin, Zhao, Xian-Lin, Chen, Huan, Kang, Hong-Xin, Zhao, Jian-Lei, Wan, Mei-Hua, Li, Juan, Zhu, Lv, Tang, Wen-Fu
Médium: Artigo
Jazyk:Inglês
Vydáno: Baishideng Publishing Group Inc 2017
Témata:
Basic Study
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5656457/
https://ncbi.nlm.nih.gov/pubmed/29093618
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3748/wjg.v23.i39.7098
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