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Distortion of histone octamer core promotes nucleosome mobilization by a chromatin remodeler
ATP-dependent chromatin remodeling enzymes play essential biological roles by mobilizing nucleosomal DNA. Yet how DNA is mobilized despite the steric constraints placed by the histone octamer remains unknown. Here, using methyl transverse-relaxation-optimized NMR spectroscopy on a 450 kDa complex, w...
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| Publicado en: | Science |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2017
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5656449/ https://ncbi.nlm.nih.gov/pubmed/28104838 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aaa3761 |
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