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Inhibition of DYRK1A disrupts neural lineage specificationin human pluripotent stem cells

Genetic analysis has revealed that the dual specificity protein kinase DYRK1A has multiple roles in the development of the central nervous system. Increased DYRK1A gene dosage, such as occurs in Down syndrome, is known to affect neural progenitor cell differentiation, while haploinsufficiency of DYR...

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Detalhes bibliográficos
Publicado no:eLife
Main Authors: Bellmaine, Stephanie F, Ovchinnikov, Dmitry A, Manallack, David T, Cuddy, Claire E, Elefanty, Andrew G, Stanley, Edouard G, Wolvetang, Ernst J, Williams, Spencer J, Pera, Martin
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5656431/
https://ncbi.nlm.nih.gov/pubmed/28884684
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.24502
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