Condensin II and GAIT complexes cooperate to restrict LINE-1 retrotransposition in epithelial cells

LINE-1 (L1) retrotransposons can mobilize (retrotranspose) within the human genome, and mutagenic de novo L1 insertions can lead to human diseases, including cancers. As a result, cells are actively engaged in preventing L1 retrotransposition. This work reveals that the human Condensin II complex re...

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Publicat a:PLoS Genet
Autors principals: Ward, Jacqueline R., Vasu, Kommireddy, Deutschman, Emily, Halawani, Dalia, Larson, Peter A., Zhang, Dongmei, Willard, Belinda, Fox, Paul L., Moran, John V., Longworth, Michelle S.
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2017
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5656329/
https://ncbi.nlm.nih.gov/pubmed/29028794
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1007051
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