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Host sphingosine kinase 1 worsens pancreatic cancer peritoneal carcinomatosis

BACKGROUND: There are no effective treatments for pancreatic cancer peritoneal carcinomatosis (PC) or cancer dissemination in abdominal cavity. Sphingosine-1-phosphate (S1P), a bioactive lipid mediator produced by sphingosine kinases (SphK1 and SphK2), plays critical roles in cancer progression. We...

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Detalhes bibliográficos
Publicado no:J Surg Res
Main Authors: Aoki, Hiroaki, Aoki, Masayo, Katsuta, Eriko, Ramanathan, Rajesh, Idowu, Michael O., Spiegel, Sarah, Takabe, Kazuaki
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5656061/
https://ncbi.nlm.nih.gov/pubmed/27664902
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jss.2016.05.034
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