Conditional Disruption of miR17∼92 in Osteoclasts Led to Activation of Osteoclasts and Loss of Trabecular Bone in Part Through Suppression of the miR17‐Mediated Downregulation of Protein‐Tyrosine Phosphatase‐oc in Mice

This study sought to understand the regulation of an osteoclastic protein‐tyrosine phosphatase (PTP‐oc), a positive regulator of osteoclast activity. Our past studies suggested that PTP‐oc is regulated posttranscriptionally. The 3′‐untranslated region (UTR) of PTP‐oc mRNA contains a target site for...

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Detalhes bibliográficos
Publicado no:JBMR Plus
Main Authors: Lau, Kin‐Hing William, Stiffel, Virginia M, Rundle, Charles H, Amoui, Mehran, Tapia, Jordan, White, Tyler D, Sheng, Matilda H‐C
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2017
Assuntos:
Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5656011/
https://ncbi.nlm.nih.gov/pubmed/29082358
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jbm4.10014
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