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Heat shock protein 47 and 65-kDa FK506-binding protein weakly but synergistically interact during collagen folding in the endoplasmic reticulum

Collagen is the most abundant protein in the extracellular matrix in humans and is critical to the integrity and function of many musculoskeletal tissues. A molecular ensemble comprising more than 20 molecules is involved in collagen biosynthesis in the rough endoplasmic reticulum. Two proteins, hea...

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Foilsithe in:J Biol Chem
Main Authors: Ishikawa, Yoshihiro, Holden, Paul, Bächinger, Hans Peter
Formáid: Artigo
Teanga:Inglês
Foilsithe: American Society for Biochemistry and Molecular Biology 2017
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5655501/
https://ncbi.nlm.nih.gov/pubmed/28860186
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M117.802298
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